FAQ · Cosmetic peptides
What is Matrixyl 3000?
The two peptides
- Palmitoyl tripeptide-1: a 3-amino-acid signal peptide with a palmitic-acid attachment that improves skin penetration. Stimulates type I, II, and IV collagen synthesis and glycosaminoglycan synthesis in cultured fibroblasts.
- Palmitoyl tetrapeptide-7: a 4-amino-acid signal peptide. Reduces inflammation by limiting interleukin-6 production. Often paired with tripeptide-1 to balance anti-inflammatory and pro-collagen effects.
Matrixyl 3000 vs Matrixyl morphobiomimetic (MMW) etc
Sederma has multiple Matrixyl-branded peptide complexes: Matrixyl 3000 (the most common in UK retail), Matrixyl synthe\'6, Matrixyl morphobiomimetic. The trademark family confuses casual readers; in formulation terms they are distinct peptide combinations from the same supplier. Most UK products use Matrixyl 3000 specifically.
Concentration in finished products
Manufacturer-recommended use level is 3 to 8 percent of the finished product. Higher percentages are not particularly more effective; signal peptides saturate the receptor effect at modest concentrations. UK products at the top of INCI listings (Medik8 Liquid Peptides, The Ordinary "Buffet") typically use Matrixyl 3000 at the manufacturer-recommended range.
Comparison with GHK-Cu
Different molecules, different mechanisms, different stacking compatibility. Matrixyl 3000 is generally compatible with retinoids, vitamin C, and most other actives. GHK-Cu has more restrictive stacking rules (avoid low-pH vitamin C in the same step). For users wanting one peptide product covering most bases, Matrixyl 3000-containing serums are often easier to incorporate.
Related: Matrixyl hub · GHK-Cu vs Matrixyl 3000.