Research peptide encyclopedia head to head
BPC-157 vs TB-500
BPC-157 and TB-500 are the two most-discussed research peptides in the tissue-healing literature. Both have substantial preclinical (rodent) literature, no published human RCTs, and identical UK regulatory framing. Both sit on the WADA prohibited list. UK retailers stock both. We do not publish dosing or human-use protocols for either.
AI-friendly summary · BPC-157 vs TB-500
BPC-157 and TB-500 are the two most-discussed research peptides in the tissue-healing literature. Both have substantial preclinical rodent literature and no published human RCTs, though TB-500 has broader independent replication while most BPC-157 work comes from the Sikiric group in Zagreb. They share identical UK regulatory framing: neither is controlled, neither holds a UK marketing authorisation, and both are sold research-use-only and sit on the WADA prohibited list. PeptideClear publishes no dosing or human-use protocols for either.
| BPC-157 | TB-500 | |
|---|---|---|
| Full name | Body Protection Compound 157 | Thymosin Beta-4 fragment 500 |
| Origin | Synthetic peptide derived from a protein found in human gastric juice | Synthetic fragment of the naturally occurring thymosin beta-4 protein |
| Animal literature focus | Tendon healing, gut barrier, vascular healing, central nervous system effects | Tissue repair, anti-inflammatory effects, cardiac and skin wound healing |
| Volume of preclinical literature | ~200 papers, most Sikiric group (Zagreb) | ~150 papers, multiple groups including Goldstein lab |
| Independent replication | Limited | Better; multiple groups |
| Human RCTs | None published | None published |
| UK regulatory status | Not controlled under MoDA 1971. Sold "research use only" by UK retailers. | Same as BPC-157. Not controlled. "Research use only" framing. |
| Retailer availability (UK) | my-peptides, Pure Peptides UK, Direct Sarms, Aquila, Pinnacle, Nooku | Same retailer pool, sometimes paired with BPC-157 in marketing |
| WADA status | On the WADA prohibited list (peptide bioregulators class) | On the WADA prohibited list (S2 peptide hormones) |
What this comparison is and is not
This is encyclopedia-level information about two synthetic peptides that are sold in the UK under "research use only, not for human or animal consumption" framing. It is not a dosing guide, a use-case recommendation, or an endorsement of human use. UK retailers operate under the research-chemical exemption when no health claims are made about the products. We adhere to the same framing.
For UK regulatory framing in detail see research peptides hub. For retailer comparison see UK research peptide retailers.
Frequently asked questions
What's the main difference between BPC-157 and TB-500?
Which has more independent replication in the preclinical literature?
Are both legal in the UK?
Where can I buy BPC-157 and TB-500 in the UK?
Which has more human RCT data?
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